Protective vaccination in the horse against Streptococcus equi with recombinant antigens
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Recombinant Streptococcus equi proteins protect mice in challenge experiments and induce immune response in horses.
Horses that have undergone infection caused by Streptococcus equi subspecies equi (strangles) were found to have significantly increased serum antibody titers against three previously characterized proteins, FNZ (cell surface-bound fibronectin binding protein), SFS (secreted fibronectin binding protein), and EAG (alpha2-macroglobulin, albumin, and immunoglobulin G [IgG] binding protein) from S....
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The secreted Mac protein made by group A Streptococcus (GAS) inhibits opsonophagocytosis of GAS by human polymorphonuclear leukocytes (PMNs). This protein also has the endopeptidase activity against human immunoglobulin G (IgG), and the Cys94, His262 and Asp284 are critical for the enzymatic activity. The horse pathogen Streptococcus equi subspecies equi produces a homologue of Mac (SeMac). SeM...
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Streptococcus equi subspecies equi (S. equi) is a clonal, equine host-adapted pathogen of global importance that causes a suppurative lymphodendopathy of the head and neck, more commonly known as Strangles. The disease is highly prevalent, can be severe and is highly contagious. Antibiotic treatment is usually ineffective. Live attenuated vaccine strains of S. equi have shown adverse reactions ...
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متن کاملCollagen-like Proteins in Horse Pathogenic Streptococcus equi
Karlström, Å. 2005. Collagen-like proteins in horse pathogenic Streptococcus equi Doctoral dissertation ISSN 1652-6880, ISBN 91-576-6998-8 Streptococcus equi subspecies equi is the causative agent of strangles, a respiratory disease that affects horses worldwide. Like other pathogenic bacteria, S. equi subspecies equi expresses a number of extracellular proteins important for the interaction wi...
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تاریخ انتشار 2009